Bokeriia L A, Arakelian V S, Ivanova S M, Serov R A, Sukhareva T V, Shubaeva N O
Vestn Ross Akad Med Nauk. 2005(4):75-81.
Aortic aneurysm is a polyethiologic disease associated with high disability and perioperative mortality rate. The evolution of ethiopathogenesis of aortic aneurysm development is considered in the article. The findings of recent worldwide studies on immune status impact on the disease progress and the postoperative period are presented. All studies showed that 25% of patients had immune status disturbances accompanied by changes in the hemostasis system and high apoptosis index in blood serum and aneurysm tissue. Variants of clinical course of different aortic aneurysm forms and perioperative managements of patients aimed at prevention of possible complications are highlighted.
主动脉瘤是一种多病因疾病，伴有高致残率和围手术期死亡率。本文探讨了主动脉瘤发生发展的病因发病机制演变。介绍了近期全球范围内关于免疫状态对疾病进展及术后影响的研究结果。所有研究均表明，25%的患者存在免疫状态紊乱，伴有止血系统改变以及血清和动脉瘤组织中的高凋亡指数。文中强调了不同类型主动脉瘤的临床病程变化以及旨在预防可能并发症的患者围手术期管理措施。
