DeCaprio Anthony P, Johnson Glenn W, Tarbell Alice M, Carpenter David O, Chiarenzelli Jeffrey R, Morse Gayle S, Santiago-Rivera Azara L, Schymura Maria J
Institute for Health and the Environment, University at Albany, State University of New York, Albany, NY 12144, USA.
Environ Res. 2005 Jul;98(3):284-302. doi: 10.1016/j.envres.2004.09.004.
The major determinants of human polychlorinated biphenyl (PCB) body burden include the source and route of exposure and the toxicokinetic processes occurring after uptake. However, the relative importance of each factor for individual subjects cannot currently be determined. The present study characterizes levels and patterns of PCB congeners in a large cohort of adult Akwesasne Mohawks with historical PCB exposure. Total serum PCB ranged from 0.29 to 48.32 ng/g and was higher in adult men than in women (median of 3.81 vs. 2.94 ng/g). The mean serum congener profile for the full cohort was dominated by persistent penta- to hepta-chlorinated biphenyls; several labile congeners were also prominent. In order to provide additional information on individual body burden determinants, multivariate exploratory data analysis techniques were applied to the congener-specific serum PCB data. A self-training receptor model, polytopic vector analysis (PVA), was employed to determine the number, composition, and relative proportions of independent congener patterns that contributed to the overall serum PCB profile for each Mohawk subject. PVA identified five such patterns, each of which was characterized by a unique mix of congeners. One pattern observed in a limited number of Mohawks was similar to those reported for air sampled near contaminated sediment deposits at Akwesasne and for volatilized Aroclor 1248 and is hypothesized to reflect recent inhalation exposure in these subjects. A second pattern was consistent with unaltered Aroclor 1254. A third pattern, resembling Aroclor 1262 but without labile congeners, was correlated with age and is interpreted as representing a lifetime PCB accumulation profile. The final two patterns were dominated by subsets of major persistent congeners and are hypothesized to reflect intermediate bioaccumulation profiles and/or differences in individual toxicokinetics. The results confirm the utility of a multivariate exploratory analysis approach to congener-specific PCB data and provide additional insight into the exposure and individual factors that determine PCB body burden in this population.
人体多氯联苯（PCB）体内负荷的主要决定因素包括接触源、接触途径以及摄入后发生的毒物动力学过程。然而，目前尚无法确定每个因素对个体的相对重要性。本研究对一大群有PCB接触史的成年阿克瓦斯奈莫霍克人队列中PCB同系物的水平和模式进行了表征。血清总PCB含量在0.29至48.32 ng/g之间，成年男性高于女性（中位数分别为3.81 ng/g和2.94 ng/g）。整个队列的平均血清同系物谱以持久性五氯至七氯联苯为主；几种不稳定的同系物也很突出。为了提供关于个体体内负荷决定因素的更多信息，对同系物特异性血清PCB数据应用了多变量探索性数据分析技术。采用自训练受体模型——多主题向量分析（PVA），来确定构成每个莫霍克受试者总体血清PCB谱的独立同系物模式的数量、组成和相对比例。PVA识别出了五种这样的模式，每种模式都具有独特的同系物组合特征。在少数莫霍克人身上观察到的一种模式与在阿克瓦斯奈受污染沉积物附近采集的空气样本以及挥发的氯丹1248中报告的模式相似，据推测这反映了这些受试者近期的吸入接触。第二种模式与未改变的氯丹1254一致。第三种模式类似于氯丹1262，但没有不稳定的同系物，与年龄相关，被解释为代表一生的PCB积累谱。最后两种模式以主要持久性同系物的子集为主，据推测反映了中间生物积累谱和/或个体毒物动力学差异。结果证实了对同系物特异性PCB数据进行多变量探索性分析方法的实用性，并为该人群中决定PCB体内负荷的接触和个体因素提供了更多见解。
