骨髓干细胞是具有可塑性还是异质性——这就是问题所在。

Are bone marrow stem cells plastic or heterogenous--that is the question.

作者信息

Kucia Magda, Ratajczak Janina, Ratajczak Mariusz Z

机构信息

Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.

出版信息

Exp Hematol. 2005 Jun;33(6):613-23. doi: 10.1016/j.exphem.2005.01.016.

DOI:10.1016/j.exphem.2005.01.016

PMID:15911085

Abstract

The concept that bone marrow (BM) may contain heterogeneous populations of stem cells was surprisingly not taken carefully enough into consideration in several recently reported experiments demonstrating so-called plasticity or trans-dedifferentiation of hematopoietic stem cells (HSC). These studies, without including proper controls to exclude this possibility, often lead to wrong interpretations. Accumulated evidence suggests that in addition to hematopoietic stem cells (HSC), bone marrow (BM) also harbors versatile subpopulations of tissue-committed stem cells (TCSC) and perhaps even more primitive pluripotent stem cells (PSC), and that these rare cells accumulate in bone marrow during ontogenesis, and being a mobile population of cells are released from BM into peripheral blood after tissue injury to regenerate damaged organs. Thus, the presence of TCSC/PSC in BM tissue should be considered before experimental evidence is interpreted simply as trans-dedifferentiation/plasticity of HSC. In this review, we will discuss this alternative explanation of plasticity of HSC, providing data from others and our laboratory that supports the concept that BM-derived stem cells are heterogeneous.

摘要

骨髓（BM）可能含有异质性干细胞群体这一概念，在最近一些报道的、证明造血干细胞（HSC）具有所谓可塑性或转分化的实验中，竟然没有得到足够仔细的考虑。这些研究在没有纳入适当对照以排除这种可能性的情况下，常常导致错误的解读。越来越多的证据表明，除了造血干细胞（HSC）之外，骨髓（BM）还含有组织定向干细胞（TCSC）的多能亚群，甚至可能还有更原始的多能干细胞（PSC），并且这些稀有细胞在个体发育过程中在骨髓中积累，作为一群可移动的细胞，在组织损伤后从骨髓释放到外周血中以再生受损器官。因此，在将实验证据简单解释为HSC的转分化/可塑性之前，应该考虑BM组织中TCSC/PSC的存在。在这篇综述中，我们将讨论对HSC可塑性的这种替代性解释，提供来自其他研究以及我们实验室的数据，这些数据支持BM来源的干细胞是异质性的这一概念。