Tang Bo, Jia Baoxiu, Shi Xifeng
College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, PR China.
Spectrochim Acta A Mol Biomol Spectrosc. 2005 Jul;61(9):2203-9. doi: 10.1016/j.saa.2004.08.019.
The supramolecular interaction of dequalinium chloride (DQC) and beta-cyclodextrin has been studied by flow injection spectrofluorimetry. The results showed that beta-CD reacted with DQC to form a 1:1 host:guest complex with an apparent association constant of 4.99 x 10(2) L mol(-1). Based on the enhancement of the fluorescence intensity of DQC, a flow injection spectrofluorometric method for the determination of DQC in bulk aqueous solution in the presence of beta-CD was developed. The linear range was 0.0412-30.00 microg mL(-1). The detection limit was 12.3 ng mL(-1) with a sampling rate of 80 h(-1). There was no interference from the excipients normally used in tablets and serum compositions. The proposed method was successfully applied to the determination of DQC in tablets and serum.
采用流动注射荧光光谱法研究了氯化喹哑啉（DQC）与β-环糊精的超分子相互作用。结果表明，β-环糊精与DQC反应形成1:1的主客体配合物，表观缔合常数为4.99×10² L mol⁻¹。基于DQC荧光强度的增强，建立了一种在β-环糊精存在下测定大量水溶液中DQC的流动注射荧光光谱法。线性范围为0.0412 - 30.00 μg mL⁻¹。在采样速率为80 h⁻¹时，检测限为12.3 ng mL⁻¹。片剂和血清组合物中常用的辅料无干扰。该方法成功应用于片剂和血清中DQC的测定。
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