Herman Arnold G, Moncada Salvador
Division of Pharmacology, University of Antwerpen, Campus Drie Eiken, Wilrijk, B-2610 Antwerpen, Belgium.
Eur Heart J. 2005 Oct;26(19):1945-55. doi: 10.1093/eurheartj/ehi333. Epub 2005 May 23.
Well-known risk factors for atherosclerosis include hypercholesterolaemia, hypertension, diabetes, and smoking. These conditions are associated with endothelial dysfunction, which itself is associated with reduced endothelial generation of nitric oxide (NO). This is an overview of the implications of NO generation in atherosclerosis and of the potential therapeutic benefit of drugs which donate NO, such as organic nitrates, nicorandil, and sydnonimines, or those which increase the availability of endogenous NO, such as statins, angiotensin-converting enzyme inhibitors, L-arginine, and tetrahydrobiopterin.
动脉粥样硬化的知名风险因素包括高胆固醇血症、高血压、糖尿病和吸烟。这些情况与内皮功能障碍有关，而内皮功能障碍本身又与内皮一氧化氮（NO）生成减少有关。本文综述了NO生成在动脉粥样硬化中的影响以及诸如有机硝酸盐、尼可地尔和西地那非等释放NO的药物或诸如他汀类药物、血管紧张素转换酶抑制剂、L-精氨酸和四氢生物蝶呤等增加内源性NO可用性的药物的潜在治疗益处。
