Waldstein Shari R, Katzel Leslie I
Department of Psychology, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
Neurology. 2005 May 24;64(10):1746-9. doi: 10.1212/01.WNL.0000161851.01243.62.
To examine the relation of stress-induced blood pressure (BP) reactivity to cognitive function.
Ninety-four healthy stroke- and dementia-free middle-aged and older adults (ages 54 to 79; 62% male; 90% white) completed biomedical, psychophysiological, and neuropsychological assessment procedures.
After statistical adjustment for age, education, state anxiety, fasting glucose levels, and resting systolic or diastolic BP (depending on the model), greater systolic BP reactivity was associated with decreased performance on Logical Memory-Immediate Recall (r2 = 0.08; p < 0.007), Logical Memory-Delayed Recall (r2 = 0.06; p < 0.02), and Stroop interference scores (r2 = 0.04; p < 0.05). Enhanced diastolic BP reactivity was similarly associated with decreased performance on Logical Memory-Immediate Recall (r2 = 0.06; p < 0.02) and Stroop interference scores (r2 = 0.06; p < 0.02).
Independent of resting clinic blood pressure (BP), systolic and diastolic BP reactivity was associated with diminished performance on tests of immediate and delayed verbal memory and executive function (i.e., response inhibition), accounting for 3 to 8% of the variance in these measures.
研究应激诱导的血压反应性与认知功能之间的关系。
94名无中风和痴呆的健康中老年人（年龄54至79岁；62%为男性；90%为白人）完成了生物医学、心理生理学和神经心理学评估程序。
在对年龄、教育程度、状态焦虑、空腹血糖水平以及静息收缩压或舒张压（取决于模型）进行统计调整后，收缩压反应性增强与逻辑记忆即时回忆（r2 = 0.08；p < 0.007）、逻辑记忆延迟回忆（r2 = 0.06；p < 0.02）以及Stroop干扰得分（r2 = 0.04；p < 0.05）的表现下降相关。舒张压反应性增强同样与逻辑记忆即时回忆（r2 = 0.06；p < 0.02）和Stroop干扰得分（r2 = 0.06；p < 0.02）的表现下降相关。
独立于静息诊所血压（BP）之外，收缩压和舒张压反应性与即时和延迟言语记忆以及执行功能（即反应抑制）测试中的表现下降相关，占这些测量指标中变异的3%至8%。
