来自合成四螺旋束四核Cu4S4辅因子的Cu(I)发光。

Cu(I) luminescence from the tetranuclear Cu4S4 cofactor of a synthetic 4-helix bundle.

作者信息

Kharenko Olesya A, Kennedy David C, Demeler Borries, Maroney Michael J, Ogawa Michael Y

机构信息

Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA.

出版信息

J Am Chem Soc. 2005 Jun 1;127(21):7678-9. doi: 10.1021/ja042757m.

DOI:10.1021/ja042757m

PMID:15913348

Abstract

The addition of Cu(I) to the random-coil peptide, C16C19-GGY, produces a self-organized, metal-bridged 4-helix bundle which displays an intense room-temperature luminescence at 600 nm. Emission, UV, and CD titrations along with X-ray absorption studies indicate that the luminescent cofactor is likely a Cu4S4 cluster in which each Cu atom is bridged by the side chains of two cysteine residues and has terminal N/O ligation.

摘要

向无规卷曲肽C16C19-GGY中添加Cu(I)会产生一种自组装的、金属桥连的四螺旋束，该四螺旋束在600 nm处呈现强烈的室温发光。发射光谱、紫外光谱和圆二色光谱滴定以及X射线吸收研究表明，发光辅因子可能是一个Cu4S4簇，其中每个铜原子由两个半胱氨酸残基的侧链桥连，并具有末端氮/氧配位。