在豚鼠回肠中具有松弛活性的N-苯甲酰色胺衍生物。
Nb-benzoyltryptamine derivatives with relaxant activity in guinea-pig ileum.
作者信息
Gutierrez Stanley Juan C, de S Claudino Fladmir, Da Silva Bagnólia A, Câmara Celso A, de Almeida Reinaldo N, de Fátima V de Souza Maria, Da Silva Marcelo S, Da-Cunha Emídio V L, Barbosa-Filho José Maria
机构信息
Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, Cx. Postal 5009, 58051-970 João Pessoa, Paraíba, Brazil.
出版信息
Farmaco. 2005 Jun-Jul;60(6-7):475-7. doi: 10.1016/j.farmac.2005.04.001.
A series of derivatives analogous to Nb-benzoyltryptamine were synthesized by the Schotten-Bauman procedure. The products obtained were: Nb-4-methoxy-benzoyltryptamine, Nb-2,4-dimethoxy-benzoyltryptamine, Nb-3,4-dimethoxy-benzoyltryptamine, Nb-3,4-methylenedioxy-benzoyltryptamine and Nb-3,4,5-trimethoxy-benzoyltryptamine. They were characterized through the usual spectrometric methods (UV, IR, 1H and 13C NMR) and showed non-selective relaxant activity in guinea-pig ileum pre-contracted with acetylcholine, histamine and KCl.
通过肖滕-鲍曼法合成了一系列与 Nb-苯甲酰色胺类似的衍生物。得到的产物有：Nb-4-甲氧基-苯甲酰色胺、Nb-2,4-二甲氧基-苯甲酰色胺、Nb-3,4-二甲氧基-苯甲酰色胺、Nb-3,4-亚甲二氧基-苯甲酰色胺和 Nb-3,4,5-三甲氧基-苯甲酰色胺。通过常规光谱方法（紫外、红外、1H 和 13C 核磁共振）对它们进行了表征，并且在预先用乙酰胆碱、组胺和氯化钾收缩的豚鼠回肠中显示出非选择性松弛活性。
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