Rastrelli L, Capasso A, Pizza C, De Tommasi N, Sorrentino L
Dipartimento di Scienze Farmaceutiche, Facoltà, Università di Salerno, Penta di Fisciano (SA), Italy.
J Nat Prod. 1997 Nov;60(11):1065-9. doi: 10.1021/np960710b.
Five new protopine-type alkaloids, 3,5-di-O-methylconstrictosine (1), 5,6-dihydro-3,5-di-O-methylconstrictosine (2), 5,6-dihydroconstrictosine (3), constrictosine (4), 3-O-methylconstrictosine (5), and a novel 8-benzylberberine-type alkaloid, (-)-8 beta-(4'-hydroxybenzyl)-2,3-dimethoxyberbin-10-ol (6) were isolated from the aerial parts of Aristolochia constricta. Their structures were elucidated by physical and spectroscopic data. The results of our pharmacological experiments indicated that MeOH extract, its partially purified fraction VI and the protopine derivatives constrictosine 1-5, significantly reduced, in a dose dependent manner, the electrical, acetylcholine, and histamine contractions of the isolated guinea-pig ileum.
从马兜铃（Aristolochia constricta）地上部分分离得到了5种新的原阿片碱型生物碱，即3,5-二-O-甲基异荷包牡丹碱（1）、5,6-二氢-3,5-二-O-甲基异荷包牡丹碱（2）、5,6-二氢异荷包牡丹碱（3）、异荷包牡丹碱（4）、3-O-甲基异荷包牡丹碱（5），以及一种新型的8-苄基小檗碱型生物碱，(-)-8β-(4'-羟基苄基)-2,3-二甲氧基小檗碱-10-醇（6）。通过物理和光谱数据阐明了它们的结构。我们的药理实验结果表明，甲醇提取物、其部分纯化的组分VI以及原阿片碱衍生物异荷包牡丹碱1-5，以剂量依赖的方式显著降低了离体豚鼠回肠的电、乙酰胆碱和组胺收缩作用。
