Gray D
Department of Immunology, Royal Postgraduate Medical School, London, UK.
Semin Immunol. 1992 Feb;4(1):29-34.
Memory has long been thought of as a stable phenomenon within the immune system: once generated it lasts for a very long time. This static view of immunological memory predicts that an established population of memory cells is independent of outside influences. Recent findings, concerning the population kinetics of the peripheral pool of lymphocytes and, more directly, concerning the influence of antigen on memory cell survival, are forcing us to reassess this idea. I present here a dynamic view of immunological memory which takes into account an immune system that appears in continual flux and whose constituent cells may rely upon recurrent signals for their survival. This view of memory also makes certain predictions and these are considered.
长期以来，记忆一直被视为免疫系统中的一种稳定现象：一旦产生，它会持续很长时间。这种关于免疫记忆的静态观点预测，已建立的记忆细胞群体独立于外界影响。最近关于外周淋巴细胞池群体动力学的发现，以及更直接地关于抗原对记忆细胞存活影响的发现，正迫使我们重新评估这一观点。我在此提出一种免疫记忆的动态观点，它考虑到一个似乎处于持续变化中的免疫系统，其组成细胞的存活可能依赖于反复的信号。这种记忆观点也做出了某些预测，并对这些预测进行了探讨。
