Linton P J, Klinman N R
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037.
Semin Immunol. 1992 Feb;4(1):3-9.
Immunization leads to the generation of antibody forming cells (AFC) and secondary B cells which differ substantially from primary B cells. Based on the function of the progeny of enriched precursor cell populations, naive progenitors of memory B cells have been separated from primary AFC precursors. Precursors of memory cells: (1) require multiple antigenic stimulations to generate antibody responses which are prolonged, of increased magnitude, and generated with rapid kinetics; (2) have the capacity to form germinal centers; (3) accumulate somatic mutations; (4) display repertoire similarities with secondary B cells; and (5) can be stimulated with cross-reactive antigens. The primary AFC precursors responded with characteristic primary responses.
免疫接种会导致抗体形成细胞（AFC）和次级B细胞的产生，这些细胞与初级B细胞有很大不同。基于富集的前体细胞群体后代的功能，记忆B细胞的幼稚祖细胞已与初级AFC前体分离。记忆细胞的前体：（1）需要多次抗原刺激才能产生延长的、幅度增加且动力学快速的抗体反应；（2）有形成生发中心的能力；（3）积累体细胞突变；（4）与次级B细胞表现出 repertoire 相似性；（5）可以被交叉反应性抗原刺激。初级AFC前体以典型的初级反应作出反应。
