Hanani Menachem
Laboratory of Experimental Surgery, Hadassah University Hospital, Mount Scopus, Jerusalem 91240, Israel.
Brain Res Brain Res Rev. 2005 Jun;48(3):457-76. doi: 10.1016/j.brainresrev.2004.09.001.
Current information indicates that glial cells participate in all the normal and pathological processes of the central nervous system. Although much less is known about satellite glial cells (SGCs) in sensory ganglia, it appears that these cells share many characteristics with their central counterparts. This review presents information that has been accumulated recently on the physiology and pharmacology of SGCs. It appears that SGCs carry receptors for numerous neuroactive agents (e.g., ATP, bradykinin) and can therefore receive signals from other cells and respond to changes in their environment. Activation of SGCs might in turn influence neighboring neurons. Thus SGCs are likely to participate in signal processing and transmission in sensory ganglia. Damage to the axons of sensory ganglia is known to contribute to neuropathic pain. Such damage also affects SGCs, and it can be proposed that these cells have a role in pathological changes in the ganglia.
目前的信息表明，神经胶质细胞参与中枢神经系统的所有正常和病理过程。尽管对感觉神经节中的卫星神经胶质细胞（SGCs）了解较少，但这些细胞似乎与其中枢神经系统中的对应细胞具有许多共同特征。本综述介绍了最近积累的关于SGCs生理学和药理学的信息。似乎SGCs携带多种神经活性物质（如ATP、缓激肽）的受体，因此可以接收来自其他细胞的信号并对其环境变化做出反应。SGCs的激活可能反过来影响邻近的神经元。因此，SGCs可能参与感觉神经节中的信号处理和传递。已知感觉神经节轴突损伤会导致神经性疼痛。这种损伤也会影响SGCs，可以认为这些细胞在神经节的病理变化中起作用。
