Majano Pedro, Alonso-Lebrero José Luis, Janczyk Agnieszka, Martín-Vichez Samuel, Molina-Jiménez Francisca, Brieva Aurora, Pivel Juan Pablo, González Salvador, López-Cabrera Manuel, Moreno-Otero Ricardo
Unidad de Biología Molecular, Hospital Universitario de la Princesa, U.A.M., Madrid, Spain.
Int Immunopharmacol. 2005 Jul;5(7-8):1165-70. doi: 10.1016/j.intimp.2005.02.009. Epub 2005 Mar 16.
We have analyzed the effect of a patented glycoconjugate of natural origin, AM3 (commercially available under the name Inmunoferon) in the expression of iNOS induced by administration of LPS in mice. We have observed that oral treatment with the drug daily for 6 days reduced the levels of expression of iNOS induced by an intravenous pulse of LPS. This effect was significant in the lungs and kidneys, but it was much more marked in the liver. In addition, the levels of nitric oxide in serum were clearly decreased upon treatment with AM3. Together, these results suggest that AM3 modulates the nitric oxide response and points to a possible role for AM3 in the control of the inflammatory response.
我们分析了一种天然来源的专利糖缀合物AM3(商品名为免疫干扰素)对小鼠体内脂多糖(LPS)诱导的诱导型一氧化氮合酶(iNOS)表达的影响。我们观察到,连续6天每日口服该药物可降低LPS静脉注射脉冲诱导的iNOS表达水平。这种作用在肺和肾中显著,但在肝脏中更为明显。此外,用AM3治疗后血清中的一氧化氮水平明显降低。这些结果共同表明,AM3可调节一氧化氮反应,并指出AM3在控制炎症反应中可能发挥的作用。