非亲缘脐血移植后成年患者的人类疱疹病毒6型B亚组感染
Human herpesvirus 6 variant B infection in adult patients after unrelated cord blood transplantation.
作者信息
Tomonari Akira, Takahashi Satoshi, Ooi Jun, Iseki Tohru, Takasugi Kashiya, Uchiyama Michihiro, Konuma Takaaki, Futami Muneyoshi, Ohno Nobuhiro, Uchimaru Kaoru, Tojo Arinobu, Asano Shigetaka
机构信息
Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
出版信息
Int J Hematol. 2005 May;81(4):352-5. doi: 10.1532/IJH97.04183.
Human herpesvirus 6 variant B (HHV-6B) infection was studied in 23 adult patients who underwent cord blood transplantation (CBT). HHV-6B DNA was detected by quantitative polymerase chain reaction analysis after CBT in the sera from 15 patients (65%) at day 14 or 15 (week 2), from 16 patients (70%) at day 21 or 22 (week 3), and from 3 patients (13%) at day 28 or 29 (week 4). HHV-6B DNAemia was found in none of the 20 patients examined at day 7 or 8 (week 1). The overall incidence of HHV-6B DNAemia reached 87% (20 of 23 patients). This incidence was much higher than after unrelated bone marrow transplantation (19%, P < .0001). In CBT patients, positive HHV-6B DNAemia at week 3 was significantly associated with early skin rash (88% versus 14%, P < .005) and grade II-IV acute graft-versus-host disease (aGVHD) (69% versus 14%, P < .05). In contrast, positive HHV-6B DNAemia at week 2 was associated with neither skin rash nor aGVHD. Prospective large-scale studies are needed to determine the role of HHV-6 infection in CBT patients.
对23例接受脐血移植（CBT）的成年患者进行了人疱疹病毒6型B（HHV-6B）感染研究。脐血移植后，通过定量聚合酶链反应分析在第14或15天（第2周）从15例患者（65%）的血清中检测到HHV-6B DNA，在第21或22天（第3周）从16例患者（70%）的血清中检测到，在第28或29天（第4周）从3例患者（13%）的血清中检测到。在第7或8天（第1周）检查的20例患者中均未发现HHV-6B病毒血症。HHV-6B病毒血症的总体发生率达到87%（23例患者中的20例）。这一发生率远高于无关供体骨髓移植后的发生率（19%，P <.0001）。在接受脐血移植的患者中，第3周HHV-6B病毒血症阳性与早期皮疹（88%对14%，P <.005）和II-IV级急性移植物抗宿主病（aGVHD）（69%对14%，P <.05）显著相关。相比之下，第2周HHV-6B病毒血症阳性与皮疹和aGVHD均无关。需要进行前瞻性大规模研究以确定HHV-6感染在接受脐血移植患者中的作用。
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