Tannuri U, Sesso A, Coelho M C, Maksoud J G
Department of Pathology, São Paulo University Medical School, Brazil.
Nutrition. 1992 Mar-Apr;8(2):98-100.
The stability of the mixture of peripheral vein parenteral nutrition (PN) solution with 10% lipid emulsions (Intralipid or Lipofundin MCT) was tested during a prolonged period of refrigerated storage. The analysis included gross visual examination of the bottle, pH determination, and examination by electron microscope. The mixtures of fat emulsions with PN solution demonstrated no physical instability or pH alteration. Examination under electron microscope revealed no alterations after 4 wk, but the surface layer of fat globules was disrupted after 10 and 18 wk. This study demonstrates that complete nutritive mixtures can be prepared and stored in refrigeration for at least 4 wk before clinical use.
在长时间冷藏储存期间，对外周静脉肠外营养（PN）溶液与10%脂肪乳剂（英脱利匹特或力保肪宁中/长链脂肪乳）的混合物稳定性进行了测试。分析包括对瓶子的外观检查、pH值测定以及电子显微镜检查。脂肪乳剂与PN溶液的混合物未表现出物理不稳定性或pH值改变。电子显微镜检查显示，4周后未出现变化，但10周和18周后脂肪球的表层受到破坏。本研究表明，完整的营养混合物可在临床使用前制备并冷藏储存至少4周。
