一种用于生物微机电系统中电介导光活性生物功能化位点的制造平台。

A fabrication platform for electrically mediated optically active biofunctionalized sites in BioMEMS.

作者信息

Powers Michael A, Koev Stephan T, Schleunitz Arne, Yi Hyunmin, Hodzic Vildana, Bentley William E, Payne Gregory F, Rubloff Gary W, Ghodssi Reza

机构信息

Department of Electrical and Computer Engineering, College Park, MD 20742, USA.

出版信息

Lab Chip. 2005 Jun;5(6):583-6. doi: 10.1039/b503112e. Epub 2005 Apr 27.

DOI:10.1039/b503112e

PMID:15915249

Abstract

We report a new approach for microfluidic optical bioanalysis that is based on the electrically driven assembly of bio-components on a transparent sidewall and the optical detection of the assembled components using planar waveguides. This allows localized electrical signals for bio-assembly and optical signals for bio-detection that can easily be applied in MEMS systems. We demonstrate a BioMEMS design incorporating this scheme and its output signal when using fluorescent detection.

摘要

我们报道了一种用于微流控光学生物分析的新方法，该方法基于生物组件在透明侧壁上的电驱动组装以及使用平面波导对组装组件进行光学检测。这使得用于生物组装的局部电信号和用于生物检测的光信号能够轻松应用于微机电系统（MEMS）中。我们展示了一种结合该方案的生物微机电系统（BioMEMS）设计及其在使用荧光检测时的输出信号。