Histidine residue at position 234 of oxidosqualene-lanosterol cyclase from saccharomyces cerevisiae simultaneously influences cyclization, rearrangement, and deprotonation reactions.
作者信息
Wu Tung-Kung, Liu Yuan-Ting, Chang Cheng-Hsian
机构信息
Department of Biological Science and Technology, Center for Interdisciplinary Molecular Science, National Chiao Tung University, 300 Hsin-Chu, Taiwan, Republic of China.
出版信息
Chembiochem. 2005 Jul;6(7):1177-81. doi: 10.1002/cbic.200500084.
PMID:15915534
Abstract
摘要
相似文献
1
Histidine residue at position 234 of oxidosqualene-lanosterol cyclase from saccharomyces cerevisiae simultaneously influences cyclization, rearrangement, and deprotonation reactions.
Chembiochem. 2005 Jul;6(7):1177-81. doi: 10.1002/cbic.200500084.
2
Phenylalanine 445 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences C-Ring cyclization and deprotonation reactions.
Org Lett. 2006 Oct 12;8(21):4691-4. doi: 10.1021/ol061549r.
3
Tryptophan 232 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences rearrangement and deprotonation but not cyclization reactions.
Org Lett. 2006 Mar 30;8(7):1319-22. doi: 10.1021/ol053134w.
4
Site-saturated mutagenesis of histidine 234 of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase demonstrates dual functions in cyclization and rearrangement reactions.
J Am Chem Soc. 2006 May 17;128(19):6414-9. doi: 10.1021/ja058782p.
5
Alteration of the substrate's prefolded conformation and cyclization stereochemistry of oxidosqualene-lanosterol cyclase of Saccharomyces cerevisiae by substitution at phenylalanine 699.
Org Lett. 2010 Feb 5;12(3):500-3. doi: 10.1021/ol902694y.
6
Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase: a chemistry-biology interdisciplinary study of the protein's structure-function-reaction mechanism relationships.
Chem Rec. 2008;8(5):302-25. doi: 10.1002/tcr.20157.
7
Protein plasticity: a single amino acid substitution in the Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase generates protosta-13(17),24-dien-3beta-ol, a rearrangement product.
Org Lett. 2008 Jun 19;10(12):2529-32. doi: 10.1021/ol800799n.
8
The cysteine 703 to isoleucine or histidine mutation of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae generates an iridal-type triterpenoid.
Biochimie. 2012 Nov;94(11):2376-81. doi: 10.1016/j.biochi.2012.06.014. Epub 2012 Jun 23.
9
Mutation of isoleucine 705 of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae affects lanosterol's C/D-ring cyclization and 17α/β-exocyclic side chain stereochemistry.
Org Biomol Chem. 2011 Feb 21;9(4):1092-7. doi: 10.1039/c0ob00582g. Epub 2010 Dec 15.
10
Access of the substrate to the active site of squalene and oxidosqualene cyclases: comparative inhibition, site-directed mutagenesis and homology-modelling studies.
Biochem Soc Trans. 2005 Nov;33(Pt 5):1202-5. doi: 10.1042/BST20051202.
Zotero 插件