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本文引用的文献

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Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice.近交系小鼠在放射状迷宫中学习空间定向任务及海马体的结构变化。
Behav Brain Funct. 2005 Apr 22;1(1):3. doi: 10.1186/1744-9081-1-3.
2
Prenatal alcohol exposure causes long-term serotonin neuron deficit in mice.孕期酒精暴露会导致小鼠长期的血清素神经元缺乏。
Alcohol Clin Exp Res. 2004 Jun;28(6):941-8. doi: 10.1097/01.alc.0000128228.08472.39.
3
A mouse model of prenatal ethanol exposure using a voluntary drinking paradigm.
在小鼠大脑齿状回门区的苔藓纤维中发现 ArfGAP1 高度丰富。
PLoS One. 2017 Dec 14;12(12):e0189659. doi: 10.1371/journal.pone.0189659. eCollection 2017.
4
Strain-specific programming of prenatal ethanol exposure across generations.跨代的产前乙醇暴露的品系特异性编程。
Alcohol. 2017 May;60:191-199. doi: 10.1016/j.alcohol.2017.01.002. Epub 2017 Jan 4.
5
The impact of prenatal alcohol exposure on social, cognitive and affective behavioral domains: Insights from rodent models.产前酒精暴露对社会、认知和情感行为领域的影响：来自啮齿动物模型的见解。
Alcohol. 2016 Mar;51:1-15. doi: 10.1016/j.alcohol.2015.12.002. Epub 2016 Jan 11.
6
Low dose prenatal alcohol exposure does not impair spatial learning and memory in two tests in adult and aged rats.低剂量产前酒精暴露在成年和老年大鼠的两项测试中不会损害空间学习和记忆。
PLoS One. 2014 Jun 30;9(6):e101482. doi: 10.1371/journal.pone.0101482. eCollection 2014.
一种使用自愿饮酒模式的产前乙醇暴露小鼠模型。
Alcohol Clin Exp Res. 2003 Dec;27(12):2009-16. doi: 10.1097/01.ALC.0000100940.95053.72.
4
Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests.小鼠乙醇中毒三种测量方法中的品系差异：筛板试验、圆棒试验和握力试验。
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5
Harnessing the mouse to unravel the genetics of human disease.利用小鼠来揭示人类疾病的遗传学奥秘。
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6
Evidence for general cognitive ability (g) in heterogeneous stock mice and an analysis of potential confounds.
Genes Brain Behav. 2002 May;1(2):88-95. doi: 10.1034/j.1601-183x.2002.10204.x.
7
Effects of embryonic exposure to ethanol on zebrafish visual function.胚胎期暴露于乙醇对斑马鱼视觉功能的影响。
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9
Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse.脆性X智力低下基因1敲除小鼠的行为学和神经解剖学特征
Hippocampus. 2002;12(1):39-46. doi: 10.1002/hipo.10005.
10
Behavioral and neuroanatomical characterization of FVB/N inbred mice.FVB/N近交系小鼠的行为和神经解剖学特征
Brain Res Bull. 2002 Jan 1;57(1):41-7. doi: 10.1016/s0361-9230(01)00635-9.

孕期暴露于酒精对三种近交系小鼠的放射状迷宫学习能力和海马苔藓纤维大小没有影响。

Prenatal exposure to alcohol does not affect radial maze learning and hippocampal mossy fiber sizes in three inbred strains of mouse.

作者信息

Sluyter Frans, Jamot Laure, Bertholet Jean-Yves, Crusio Wim E

机构信息

Laboratoire de Neurosciences Cognitives, CNRS UMR 5106 Avenue des Facultés 33405 Talence France.

出版信息

Behav Brain Funct. 2005 Apr 22;1(1):5. doi: 10.1186/1744-9081-1-5.

DOI:10.1186/1744-9081-1-5
PMID:15916699
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1143778/
Abstract

BACKGROUND

The aim of this study was to investigate the effects of prenatal alcohol exposure on radial-maze learning and hippocampal neuroanatomy, particularly the sizes of the intra- and infrapyramidal mossy fiber (IIPMF) terminal fields, in three inbred strains of mice (C57BL/6J, BALB/cJ, and DBA/2J). RESULTS: Although we anticipated a modification of both learning and IIPMF sizes, no such effects were detected. Prenatal alcohol exposure did, however, interfere with reproduction in C57BL/6J animals and decrease body and brain weight (in interaction with the genotype) at adult age. CONCLUSION: Prenatal alcohol exposure influenced neither radial maze performance nor the sizes of the IIPMF terminal fields. We believe that future research should be pointed either at different targets when using mouse models for Fetal Alcohol Syndrome (e.g. more complicated behavioral paradigms, different hippocampal substructures, or other brain structures) or involve different animal models.

摘要

背景

本研究旨在调查孕期酒精暴露对三种近交系小鼠（C57BL/6J、BALB/cJ和DBA/2J）放射状迷宫学习及海马神经解剖结构的影响，尤其是锥体内和锥体下苔藓纤维（IIPMF）终末场的大小。结果：尽管我们预期学习能力和IIPMF大小会发生改变，但未检测到此类影响。然而，孕期酒精暴露确实干扰了C57BL/6J动物的繁殖，并降低了成年时的体重和脑重（与基因型相互作用）。结论：孕期酒精暴露既不影响放射状迷宫表现，也不影响IIPMF终末场的大小。我们认为，未来的研究应要么在将小鼠模型用于胎儿酒精综合征时针对不同的目标（例如更复杂的行为范式、不同的海马亚结构或其他脑结构），要么采用不同的动物模型。

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