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N,N'-Bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine stabilized a single pyrimidine bulge in duplex DNA.

作者信息

Suda Hitoshi, Kobori Akio, Zhang Jinhua, Hayashi Gosuke, Nakatani Kazuhiko

机构信息

Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Kyoto 615-8510, Japan.

出版信息

Bioorg Med Chem. 2005 Jul 15;13(14):4507-12. doi: 10.1016/j.bmc.2005.04.035.

DOI:10.1016/j.bmc.2005.04.035
PMID:15916896
Abstract

We here show the first identified ligand 2,7-diamino-1,8-naphthyridine (DANP) that strongly and specifically binds to the single cytosine and thymine bulges with exclusively 1:1 stoichiometry.

摘要

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