Sjölander Annica, Minthon Lennart, Bogdanovic Nenad, Wallin Anders, Zetterberg Henrik, Blennow Kaj
Department of Clinical Neuroscience, Unit of Neurochemistry, The Sahlgrenska Academy at Göteborg University, Sweden.
Neurobiol Aging. 2009 Apr;30(4):666-8. doi: 10.1016/j.neurobiolaging.2007.07.018. Epub 2007 Sep 11.
Recently, a single nucleotide polymorphism (SNP, rs1800206) in the peroxisome proliferator-activated receptor alpha (PPAR-alpha) gene has been proposed to be associated with Alzheimer's disease (AD). To verify this finding, we analyzed the PPAR-alpha SNP in 461 patients with AD and 1395 controls. In subgroups, PPAR-alpha gene data could be investigated in relation to biochemical and neuropathological markers for AD. We found no significant differences in genotype or allele distributions between AD patients and controls. None of the PPAR-alpha gene variants influenced markers for AD.
最近，有人提出过氧化物酶体增殖物激活受体α（PPAR-α）基因中的单核苷酸多态性（SNP，rs1800206）与阿尔茨海默病（AD）有关。为了验证这一发现，我们分析了461例AD患者和1395例对照者的PPAR-α SNP。在亚组中，可以研究PPAR-α基因数据与AD的生化和神经病理学标志物的关系。我们发现AD患者和对照者之间在基因型或等位基因分布上没有显著差异。PPAR-α基因的变体均未影响AD的标志物。
