Rankin Shelley, Roberts Scott, O'Shea Kathleen, Maloney Donna, Lorenzo Marianne, Benson Charles E
Mathew J. Ryan Veterinary Hospital, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA 19104, USA.
Vet Microbiol. 2005 Jun 15;108(1-2):145-8. doi: 10.1016/j.vetmic.2005.02.013. Epub 2005 Apr 21.
Methicillin-resistant Staphylococcus aureus (MRSA) is a highly pathogenic multiple-drug resistant (MDR) microorganism that has recently become more prevalent in the community. It has been found that MRSA strains can also contain genes that encode the panton valentine leukocidin toxin (PVL). The PVL toxin has been shown to be responsible for many of the severe clinical symptoms of infection with MRSA, such as furunculosis, severe necrotizing pneumonia, and necrotic lesions of the skin and soft tissues. The aim of this study was to determine the presence of the S. aureus PVL toxin genes (lukS-PV and lukF-PV) in MRSA strains isolated from companion animals. Eleven MRSA isolates, from a total of 23 tested, were shown to possess the mecA gene and the PVL toxin genes. Pulsed-field gel electrophoresis showed that the 11 PVL toxin positive MRSA strains were highly clonal.
耐甲氧西林金黄色葡萄球菌（MRSA）是一种高致病性的多重耐药（MDR）微生物，最近在社区中变得更为普遍。已发现MRSA菌株还可含有编码杀白细胞素毒素（PVL）的基因。PVL毒素已被证明是导致许多MRSA感染严重临床症状的原因，如疖病、严重坏死性肺炎以及皮肤和软组织的坏死性病变。本研究的目的是确定从伴侣动物分离出的MRSA菌株中金黄色葡萄球菌PVL毒素基因（lukS-PV和lukF-PV）的存在情况。在总共检测的23株中，有11株MRSA分离株被证明具有mecA基因和PVL毒素基因。脉冲场凝胶电泳显示，这11株PVL毒素阳性MRSA菌株具有高度克隆性。
