扁柏酚对沙眼衣原体增殖的体外抑制作用。
In vitro inhibitory effects of hinokitiol on proliferation of Chlamydia trachomatis.
作者信息
Yamano Hiroaki, Yamazaki Tsutomu, Sato Kozue, Shiga Sadashi, Hagiwara Toshikatsu, Ouchi Kazunobu, Kishimoto Toshio
机构信息
Department of Virology 1, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, Japan 162-8640.
出版信息
Antimicrob Agents Chemother. 2005 Jun;49(6):2519-21. doi: 10.1128/AAC.49.6.2519-2521.2005.
Abstract
The inhibitory effects of hinokitiol (beta-thujaplicin) on Chlamydia trachomatis D/UW-3/Cx were shown by MIC, minimum lethal concentration (MLC), and preinoculation minimal microbicidal concentration assays using HeLa 229 cells. The MIC and the MLC were both 32 microg/ml. Further evaluation of hinokitiol as a topical agent against C. trachomatis is warranted.
摘要
通过使用HeLa 229细胞的最小抑菌浓度（MIC）、最小致死浓度（MLC）和接种前最小杀菌浓度试验，显示了扁柏酚（β-崖柏素）对沙眼衣原体D/UW-3/Cx的抑制作用。MIC和MLC均为32μg/ml。有必要进一步评估扁柏酚作为抗沙眼衣原体局部用药的效果。
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