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环丙沙星治疗腹泻患者后大肠杆菌抗菌药物敏感性率的变化

Posttreatment changes in Escherichia coli antimicrobial susceptibility rates among diarrheic patients treated with ciprofloxacin.

作者信息

Putnam Shannon D, Sanders John W, Tribble David R, Rockabrand David R, Riddle Mark S, Rozmajzl Patrick J, Frenck Robert W

机构信息

Naval Medical Research Unit 2, Jakarta, Indonesia.

出版信息

Antimicrob Agents Chemother. 2005 Jun;49(6):2571-2. doi: 10.1128/AAC.49.6.2571-2572.2005.

Abstract

Changes in antimicrobial resistance of Escherichia coli among deployed U.S. military personnel being treated for diarrhea were evaluated. Stool samples were collected pretreatment and on days 7, 14, and 28 posttreatment. Resistance to ciprofloxacin was noted in 13.3% of baseline specimens, and rates of resistance against multiple antibiotics increased dramatically from baseline to day 7 and then tapered off to return to pretreatment levels by day 28, except for ciprofloxacin, suggesting that population accumulative usage of fluoroquinolones may result in an incremental increase in resistance rates.

摘要

对正在接受腹泻治疗的美国现役军人中大肠杆菌的抗菌药物耐药性变化进行了评估。在治疗前以及治疗后第7天、14天和28天采集粪便样本。在13.3%的基线样本中发现对环丙沙星耐药,除环丙沙星外,多重抗生素耐药率从基线到第7天急剧上升,然后逐渐下降,到第28天恢复到治疗前水平,这表明氟喹诺酮类药物的人群累积使用可能导致耐药率逐步上升。

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