Zucchetto A, Tavani A, Dal Maso L, Gallus S, Negri E, Talamini R, Franceschi S, Montella M, La Vecchia C
Unita di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano (PN), Italy.
Int J Obes (Lond). 2005 Jul;29(7):798-803. doi: 10.1038/sj.ijo.0802979.
The relation of anthropometric measures, diabetes, hypertension and hyperlipidemia with benign prostatic hyperplasia (BPH) risk was investigated.
Hospital-based case-control study.
Cases were 1369 men with histologically confirmed BPH, and controls were 1451 men below 75 y, admitted to hospital for acute non-neoplastic diseases.
Using a structured questionnaire, trained interviewers collected information on self-reported height and weight, and measured waist and hip circumference of patients. The odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional multiple logistic regression models.
Compared to the corresponding lowest quartile, the OR for the highest one were 0.76 (95% CI 0.59-0.98) for body weight, 0.71 (95% CI 0.54-0.94) for waist-to-hip ratio and 0.87 (95% CI 0.70-1.09) for body mass index (BMI, kg/m(2)). Compared to a lowest lifelong BMI <20.7 kg/m(2), the OR was 1.56 (95% CI 1.25-1.95) for a lowest lifelong BMI > or =23.7 kg/m(2). The OR was 0.74 (95% CI 0.60-0.93) for a lifelong increase of BMI > or =6.1 kg/m(2), compared to <1.6 kg/m(2). No association emerged for history of diabetes, hypertension and hyperlipidemia.
Overweight was modestly, inversely related to BPH. The hypothesis of reduced testosterone levels in obese individuals may explain the different BPH risk and need to be tested.
研究人体测量指标、糖尿病、高血压和高脂血症与良性前列腺增生（BPH）风险之间的关系。
基于医院的病例对照研究。
病例为1369例经组织学确诊为BPH的男性，对照为1451例75岁以下因急性非肿瘤性疾病入院的男性。
经过培训的访谈员使用结构化问卷收集患者自我报告的身高和体重信息，并测量患者的腰围和臀围。使用无条件多因素逻辑回归模型估计比值比（OR）和95%置信区间（CI）。
与相应的最低四分位数相比，体重最高四分位数的OR为0.76（95%CI 0.59 - 0.98），腰臀比最高四分位数的OR为0.71（95%CI 0.54 - 0.94），体重指数（BMI，kg/m²）最高四分位数的OR为0.87（95%CI 0.70 - 1.09）。与终生最低BMI<20.7 kg/m²相比，终生最低BMI≥23.7 kg/m²的OR为1.56（95%CI 1.25 - 1.95）。与BMI增加<1.6 kg/m²相比，终生BMI增加≥6.1 kg/m²的OR为0.74（95%CI 0.60 - 0.93）。糖尿病、高血压和高脂血症病史未显示出相关性。
超重与BPH呈轻度负相关。肥胖个体睾酮水平降低的假说可能解释了不同的BPH风险，有待进一步验证。
