López García J S, García Lozano I, Smaranda A, Martínez-Garchitorena J
Hospital Central Cruz Roja, Madrid, España.
Arch Soc Esp Oftalmol. 2005 May;80(5):289-95. doi: 10.4321/s0365-66912005000500006.
To determine possible differences between the Schirmer test and the tear break up time (BUT) in relation to the etiology and severity of the dry eye syndrome.
We present a prospective study of 206 eyes in 106 patients (38 males and 68 females). Both the Schirmer test and BUT were performed on all of them. We divided the patients into ten etiologic groups according to the Madrid triple classification of dry eye etiology and into four groups according to clinical severity.
Both the Schirmer test and BUT results decrease according to the severity of symptoms and we found significant differences between clinical groups. In regard to etiology, we found lower values of the Schirmer test especially in immunological, senile and traumatic dry eye groups. BUT measures were lower in immunological, inflammatory and tantalic dry eye groups.
Although we found differences between Schirmer test results and BUT values according to dry eye etiology, these differences were only statistically significant between the immunological group and the other groups. Differences between etiological groups decreased with worsening of the illness due to a general affectation of the lacrimal glands.
确定泪液分泌试验（Schirmer试验）和泪膜破裂时间（BUT）在干眼综合征的病因和严重程度方面可能存在的差异。
我们对106例患者（38例男性和68例女性）的206只眼睛进行了一项前瞻性研究。对所有患者均进行了Schirmer试验和BUT检测。我们根据马德里干眼病因三重分类法将患者分为十个病因组，并根据临床严重程度分为四组。
Schirmer试验和BUT结果均随症状严重程度降低，且我们发现临床组之间存在显著差异。在病因方面，我们发现Schirmer试验值较低，尤其是在免疫性、老年性和外伤性干眼组。免疫性、炎症性和钽中毒性干眼组的BUT测量值较低。
尽管我们发现根据干眼病因，Schirmer试验结果和BUT值之间存在差异，但这些差异仅在免疫组与其他组之间具有统计学意义。由于泪腺普遍受累，病因组之间的差异随着病情加重而减小。
