El-Hajj Ihab I, Mourad Fadi H, Shabb Nina S, Barada Kassem A
Department of Internal Medicine, American University of Beirut Medical Center, PO Box, 113-6044, Hamra street, Beirut 110 32090, Lebanon.
World J Gastroenterol. 2005 May 28;11(20):3159-60. doi: 10.3748/wjg.v11.i20.3159.
A 41-year-old man presented with severe gastric ulceration 3 mo after beginning treatment with atorvastatin 20 mg once daily for hypercholesterolemia. The patient was not taking any ulcerogenic drugs and had no evidence of Helicobacter pylori infection. Proton pump inhibitor therapy was initiated and atorvastatin was replaced by simvastatin with complete resolution of gastrointestinal symptoms. To our knowledge, this is the first report of atorvastatin-induced gastric ulceration, which should be looked for in patients who develop abdominal pain while on this drug.
一名41岁男性在开始每日一次服用20毫克阿托伐他汀治疗高胆固醇血症3个月后出现严重胃溃疡。该患者未服用任何致溃疡药物，也没有幽门螺杆菌感染的证据。开始使用质子泵抑制剂治疗，并将阿托伐他汀换成辛伐他汀，胃肠道症状完全缓解。据我们所知，这是阿托伐他汀引起胃溃疡的首例报告，对于服用此药时出现腹痛的患者应考虑这一情况。
