Mackay J W, Fenech M E, Myint K S
Elise Bertman Diabetes Centre, Norfolk and Norwich University Hospital.
Br J Hosp Med (Lond). 2012 Feb;73(2):106-7. doi: 10.12968/hmed.2012.73.2.106.
Atorvastatin and warfarin are commonly prescribed in combination. Acute rhabdomyolysis is a rare but recognized side effect of atorvastatin occurring within a few weeks of initiation. This article presents a case of a 69-year-old man, on stable atorvastatin therapy, who developed acute rhabdomyolysis following initiation of warfarin. Rising international normalized ratio is a well-recognized feature of interaction between warfarin and various statins (fluvastatin, lovastatin and simva-statin). There has only been one previous similar case of acute rhabdomyolysis following the commencement of warfarin, reported in a patient on stable simvastatin therapy. To the authors' knowledge, no similar case has been reported with atorvastatin.
阿托伐他汀和华法林通常联合使用。急性横纹肌溶解症是阿托伐他汀一种罕见但已被认识到的副作用，在开始用药几周内出现。本文介绍了一名69岁男性病例，该患者正在接受稳定的阿托伐他汀治疗，在开始使用华法林后发生了急性横纹肌溶解症。国际标准化比值升高是华法林与各种他汀类药物（氟伐他汀、洛伐他汀和辛伐他汀）相互作用的一个公认特征。之前仅报道过一例在开始使用华法林后发生急性横纹肌溶解症的类似病例，该患者正在接受稳定的辛伐他汀治疗。据作者所知，尚无阿托伐他汀相关的类似病例报道。
