Coker A L, Hulka B S, McCann M F, Walton L A
Department of Epidemiology and Biostatistics, University of South Carolina, Columbia 29208.
Contraception. 1992 Jan;45(1):1-10. doi: 10.1016/0010-7824(92)90136-h.
This North Carolina-based case-control study examined risk factors for cervical intraepithelial neoplasia (CIN). Cases were 103 women with biopsy-confirmed CIN II or III who were recruited from a referral dysplasia clinic. Controls were 258 family practice patients with normal cervical cytology. All subjects were interviewed regarding their sexual and reproductive history, Pap smear screening, active and passive cigarette exposures, and contraceptive use patterns. When compared with controls, cases were half as likely to have ever used barrier methods of contraception; the adjusted odds ratio was 0.5 (95% CI 0.2-0.9). The risk of CIN II/III decreased further with increasing years of barrier method use. Recency, latency, and age at first barrier method use were all associated with a reduced risk of CIN. Men and women should carefully consider the range of benefits of barrier method use as a means to reduce their risk of unwanted pregnancies, sexually transmitted diseases, and cervical neoplasia.
这项基于北卡罗来纳州的病例对照研究调查了宫颈上皮内瘤变（CIN）的危险因素。病例为103名经活检确诊为CIN II或III级的女性，她们是从一家转诊发育异常诊所招募的。对照为258名宫颈细胞学检查正常的家庭医疗患者。所有受试者均接受了关于其性史和生殖史、巴氏涂片筛查、主动和被动吸烟暴露以及避孕使用模式的访谈。与对照组相比，病例曾经使用屏障避孕法的可能性只有对照组的一半；调整后的优势比为0.5（95%置信区间0.2 - 0.9）。随着屏障避孕法使用年限的增加，CIN II/III的风险进一步降低。首次使用屏障避孕法的近期情况、潜伏期和年龄均与CIN风险降低有关。男性和女性应仔细考虑使用屏障避孕法的一系列益处，将其作为降低意外怀孕、性传播疾病和宫颈肿瘤风险的一种手段。
