脂多糖诱导传入迷走神经激活的新途径：结状神经节的可能作用。

Novel pathway for LPS-induced afferent vagus nerve activation: possible role of nodose ganglion.

作者信息

Hosoi Toru, Okuma Yasunobu, Matsuda Tadashi, Nomura Yasuyuki

机构信息

Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo 060-0812, Japan.

出版信息

Auton Neurosci. 2005 Jun 15;120(1-2):104-7. doi: 10.1016/j.autneu.2004.11.012.

DOI:10.1016/j.autneu.2004.11.012

PMID:15919243

Abstract

The afferent vagus nerve has been suggested to be an important component for transmitting peripheral immune signals to the brain. However, there is inconsistent evidence showing that subdiaphragmatic vagotomy did not inhibit the brain mediated behavioral and neural effects induced by the peripheral application of lipopolysaccharide (LPS). LPS triggers innate immune cells through Toll-like receptor 4 (TLR4). In the present study, we found that TLR4 mRNA and protein was expressed in the rat nodose ganglion. Thus, it is suggested that LPS could activate afferent vagus nerve at the level of nodose ganglion, which exists centrally from the subdiaphragmatic level of vagus nerve. The results could provide evidence for the novel pathway of LPS-induced afferent vagus nerve activation.

摘要

传入迷走神经被认为是将外周免疫信号传递至大脑的重要组成部分。然而，有不一致的证据表明，膈下迷走神经切断术并未抑制外周应用脂多糖（LPS）所诱导的大脑介导的行为和神经效应。LPS通过Toll样受体4（TLR4）激活先天免疫细胞。在本研究中，我们发现TLR4 mRNA和蛋白在大鼠结状神经节中表达。因此，提示LPS可在结状神经节水平激活传入迷走神经，而结状神经节位于膈下迷走神经水平的中枢端。这些结果可为LPS诱导传入迷走神经激活的新途径提供证据。