细胞因子多态性不影响以他克莫司为基础的免疫抑制下肾移植的急性排斥反应。

Cytokine polymorphisms do not influence acute rejection in renal transplantation under tacrolimus-based immunosuppression.

作者信息

Loucaidou M, Stitchbury J, Lee J, Borrows R, Marshall S E, McLean A G, Cairns T, Griffith M, Hakim N, Palmer A, Papalois V, Welsh K, Taube D

机构信息

Renal and Transplant Unit, St Mary's Hospital, London, United Kingdom.

出版信息

Transplant Proc. 2005 May;37(4):1760-1. doi: 10.1016/j.transproceed.2005.03.151.

DOI:10.1016/j.transproceed.2005.03.151

PMID:15919456

Abstract

INTRODUCTION

Acute rejection remains an important cause of graft loss after renal transplantation. It has been suggested that cytokine genotyping may play a predictive role in identifying individuals who are at higher risk of acute rejection with a view to individualizing their immunosuppression. The aim of this study was to investigate any possible associations between acute rejection and certain cytokine polymorphisms.

METHODS

We genotyped 91 cadaveric renal transplant recipients on tacrolimus-based immunosuppression and 84 of their donors. The cytokine polymorphisms studied were the following: tumor necrosis factor (TNF)-alpha-1032 T/C, TNF-alpha-865 C/A, TNF-alpha-859 G/A, interleukin (IL)1-R1-970 C/T, IL-10 haplotype [-1082, -819, -592], and IL-6-174 C/G.

RESULTS

We found no association between any polymorphism and the incidence of acute rejection. This was true for both the recipient and donor population.

CONCLUSION

Cytokine polymorphisms did not influence acute rejection in our study. We conclude that in the modern era of immunosuppression cytokine genotyping is not a significant predictor of acute rejection in renal transplantation.

摘要

引言

急性排斥反应仍然是肾移植后移植肾丢失的重要原因。有人提出，细胞因子基因分型可能在识别急性排斥反应高风险个体方面发挥预测作用，以便实现免疫抑制的个体化。本研究的目的是调查急性排斥反应与某些细胞因子多态性之间的任何可能关联。

方法

我们对91例接受基于他克莫司免疫抑制治疗的尸体肾移植受者及其84例供者进行了基因分型。所研究的细胞因子多态性如下：肿瘤坏死因子（TNF）-α-1032 T/C、TNF-α-865 C/A、TNF-α-859 G/A、白细胞介素（IL）1-R1-970 C/T、IL-10单倍型[-1082, -819, -592]和IL-6-174 C/G。