Campos A R, Fischbach K F, Steller H
Howard Hughes Medical Institute, Department of Brain and Cognitive Sciences, Cambridge, MA.
Development. 1992 Feb;114(2):355-66. doi: 10.1242/dev.114.2.355.
The importance of retinal innervation for the normal development of the optic ganglia in Drosophila is well documented. However, little is known about retrograde effects of the optic lobe on the adult photoreceptor cells (R-cells). We addressed this question by examining the survival of R-cells in mutant flies where R-cells do not connect to the brain. Although imaginal R-cells develop normally in the absence of connections to the optic lobes, we find that their continued survival requires these connections. Genetic mosaic studies with the disconnected (disco) mutation demonstrate that survival of R-cells does not depend on the genotype of the eye, but is correlated with the presence of connections to the optic ganglia. These results suggest the existence of retrograde interactions in the Drosophila visual system reminiscent of trophic interactions found in vertebrates.
视网膜神经支配对果蝇视神经节正常发育的重要性已有充分记录。然而，关于视叶对成年光感受器细胞（R细胞）的逆行影响却知之甚少。我们通过检查R细胞与大脑无连接的突变果蝇中R细胞的存活情况来解决这个问题。尽管在与视叶无连接的情况下，成虫R细胞能正常发育，但我们发现它们的持续存活需要这些连接。对不连接（disco）突变进行的遗传镶嵌研究表明，R细胞的存活不依赖于眼睛的基因型，而是与对视神经节连接的存在相关。这些结果表明果蝇视觉系统中存在逆行相互作用，这让人联想到在脊椎动物中发现的营养相互作用。
