Takahashi T, Tsukahara Y
Division of Neuropsychiatry, Sendai City Hospital, Japan.
Epilepsia. 1992 May-Jun;33(3):517-21. doi: 10.1111/j.1528-1157.1992.tb01702.x.
The suppressive effect of sunglasses upon photoparoxysmal responses (PPRs) elicited by 15-Hz flicker stimuli with a low luminance of nearly 10 nits was studied in eight patients with photosensitive epilepsy. Using three commercially available sunglasses of neutral density (ND), blue, and brown, the influence upon generalized PPRs elicited by a flickering dot pattern (FDP) and red flicker (RF) stimuli was separately examined in six patients; the luminance of the visual stimuli decreased from roughly one-fifth (ND and brown sunglasses) to one-tenth (blue sunglasses). With FDP stimulation, four of the six patients wearing each of the three sunglasses had no provocation of PPRs, whereas two of the six patients had provocation of generalized PPRs with all of the sunglasses. With RF stimulation, two of the six patients wearing ND sunglasses had provocation of generalized PPRs; three of the six patients wearing brown sunglasses had similar provocation; in contrast, none of the six patients showed provocation of PPRs while wearing blue sunglasses. These results suggest that the suppressive effect of the three sunglasses on FDP stimulation is mainly due to a luminance diminution, whereas that of blue sunglasses on RF stimulation is produced by an inhibitory effect of short wavelengths and possibly by a luminance diminution. Thus, blue sunglasses are thought to be useful in the treatment of patients with photosensitive epilepsy.
在8例光敏性癫痫患者中研究了太阳镜对由低亮度（近10尼特）的15赫兹闪烁刺激诱发的光阵发性反应（PPR）的抑制作用。使用三种市售的中性密度（ND）、蓝色和棕色太阳镜，分别在6例患者中检查了对闪烁点图案（FDP）和红色闪烁（RF）刺激诱发的全身性PPR的影响；视觉刺激的亮度从大约五分之一（ND和棕色太阳镜）降低到十分之一（蓝色太阳镜）。在FDP刺激下，佩戴这三种太阳镜的6例患者中有4例未诱发PPR，而6例患者中有2例佩戴所有太阳镜时均诱发了全身性PPR。在RF刺激下，佩戴ND太阳镜的6例患者中有2例诱发了全身性PPR；佩戴棕色太阳镜的6例患者中有3例有类似的诱发情况；相比之下，6例患者中没有1例在佩戴蓝色太阳镜时出现PPR诱发。这些结果表明，三种太阳镜对FDP刺激的抑制作用主要是由于亮度降低，而蓝色太阳镜对RF刺激的抑制作用是由短波长的抑制作用以及可能的亮度降低产生的。因此，蓝色太阳镜被认为对光敏性癫痫患者的治疗有用。
