Singer C, Weiner W J, Sanchez-Ramos J R
University of Miami, School of Medicine, Department of Neurology, Fla 33136.
Eur Neurol. 1992;32(3):134-40. doi: 10.1159/000116810.
Forty-eight men with Parkinson's disease (PD) were interviewed utilizing a questionnaire which evaluated autonomic function. The study population included PD patients (mean age: 65.8 years, mean duration of PD: 8 years) and 32 elderly healthy nonparkinsonian males (mean age: 70.4 years). We found a significantly higher prevalence of the following symptoms of autonomic dysfunction in the parkinsonian patients: erectile dysfunction (60.4 vs. 37.5%), sensation of incomplete bladder emptying (41.6 vs. 15.6%), urgency (45.8 vs. 3.125%), constipation (43.9 vs. 6.25%), dysphagia (22.9 vs. 6.25%) and orthostatic dizziness (21.95 vs. 0%). Eighty-nine percent of parkinsonian patients had at least one of these autonomic symptoms, compared to 43% of control subjects (p less than 0.05). This study is the first comprehensive survey of autonomic symptomatology in PD compared to elderly healthy controls and confirms that autonomic nervous system dysfunction is a pervasive problem in PD. Erectile dysfunction is a significant problem in this patient group and contributes to deterioration in the quality of life.
我们使用一份评估自主神经功能的问卷对48名帕金森病（PD）男性患者进行了访谈。研究对象包括帕金森病患者（平均年龄：65.8岁，帕金森病平均病程：8年）和32名老年健康非帕金森病男性（平均年龄：70.4岁）。我们发现帕金森病患者中以下自主神经功能障碍症状的患病率显著更高：勃起功能障碍（60.4%对37.5%）、膀胱排空不全感（41.6%对15.6%）、尿急（45.8%对3.125%）、便秘（43.9%对6.25%）、吞咽困难（22.9%对6.25%）和体位性头晕（21.95%对0%）。89%的帕金森病患者至少有这些自主神经症状中的一种，而对照组这一比例为43%（p<0.05）。与老年健康对照组相比，本研究是对帕金森病自主神经症状的首次全面调查，并证实自主神经系统功能障碍是帕金森病中普遍存在的问题。勃起功能障碍在该患者群体中是一个重要问题，并导致生活质量下降。
