Nakai Motoki, Shiraki Tatsuya, Higashi Katsuhiko, Maeda Masako, Sahara Shinya, Takeuchi Nozomu, Kimura Masashi, Terada Masaki, Sato Morio
Department of Radiology, Hidaka General Hospital.
Nihon Igaku Hoshasen Gakkai Zasshi. 2005 Apr;65(2):124-6.
We devised low-output radiofrequency ablation (RFA)combined with transcatheter arterial chemoembolization using iodized oil mixed with anticancer drugs (TACE) for hepatocellular carcinoma (HCC), to reduce the cooling effect of tumoral arterial blood flow, to prevent intraportal disseminations and intrahepatic metastases by sudden ebullition (bumping), and to obtain an adequate margin of safety. We performed low-output RFA on 10 HCC patients. We performed RFA with a lower output of 90W or less within two weeks after TACE. After the ablation, portal venous-phase CT images showed a low-density margin of 5 mm or larger around the site of iodized-oil accumulation, indicating that the necrotic area completely included the tumor. No intrahepatic metastasis or severe complication occurred. Low-output RFA combined with TACE is a safe, effective therapy for HCC.
我们设计了低输出量射频消融术（RFA）联合经动脉化疗栓塞术（TACE），其中TACE使用与抗癌药物混合的碘化油用于治疗肝细胞癌（HCC），以减少肿瘤动脉血流的冷却效应，防止因突然沸腾（冲击）导致的门静脉内播散和肝内转移，并获得足够的安全 margins。我们对10例HCC患者进行了低输出量RFA。我们在TACE后两周内以90W或更低的较低输出量进行RFA。消融后，门静脉期CT图像显示碘化油积聚部位周围有5mm或更大的低密度边缘，表明坏死区域完全包含肿瘤。未发生肝内转移或严重并发症。低输出量RFA联合TACE是一种安全、有效的HCC治疗方法。
