阿司匹林可抑制生长激素处理动物体内胰岛素受体底物1的丝氨酸磷酸化。
Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in growth hormone treated animals.
作者信息
Prattali Raphael R, Barreiro Guilherme C, Caliseo Caio T, Fugiwara Felipe Y, Ueno Mirian, Prada Patrícia O, Velloso Licio A, Saad Mario J A, Carvalheira José B C
机构信息
Departamento de Clínica Médica, FCM, Universidade Estadual de Campinas (UNICAMP), 13081-970 Campinas, SP, Brazil.
出版信息
FEBS Lett. 2005 Jun 6;579(14):3152-8. doi: 10.1016/j.febslet.2005.04.075.
In this study, we demonstrate that pretreatment with aspirin inhibits GH-induced insulin resistance. GH was observed to lead to serine phosphorylation of IRS-1, a phenomenon which was reversed by aspirin in liver, muscle and WAT in parallel with a reduction in JNK activity. In addition, our data show an impairment of insulin activation in the IR/IRS/PI(3)kinase pathway and a reduction in IRS-1 protein levels in rats treated with GH, which was also reversed in the animals pretreated with aspirin. Overall, these results provide new insights into the mechanism of GH-induced insulin resistance.
在本研究中，我们证明阿司匹林预处理可抑制生长激素（GH）诱导的胰岛素抵抗。观察到GH会导致胰岛素受体底物1（IRS-1）的丝氨酸磷酸化，在肝脏、肌肉和白色脂肪组织（WAT）中，阿司匹林可逆转这一现象，同时JNK活性降低。此外，我们的数据显示，在接受GH治疗的大鼠中，胰岛素受体（IR）/胰岛素受体底物（IRS）/磷脂酰肌醇-3激酶（PI(3)激酶）途径中的胰岛素激活受损，IRS-1蛋白水平降低，而在接受阿司匹林预处理的动物中，这些情况也得到了逆转。总体而言，这些结果为GH诱导胰岛素抵抗的机制提供了新的见解。
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