人类DNA修复基因，2005年。

Human DNA repair genes, 2005.

作者信息

Wood Richard D, Mitchell Michael, Lindahl Tomas

机构信息

University of Pittsburgh Cancer Institute, Hillman Cancer Center, Research Pavilion, Suite 2.6, 5117 Centre Avenue, Pittsburgh, PA 15213, USA.

出版信息

Mutat Res. 2005 Sep 4;577(1-2):275-83. doi: 10.1016/j.mrfmmm.2005.03.007.

DOI:10.1016/j.mrfmmm.2005.03.007

PMID:15922366

Abstract

An updated inventory of about 150 human DNA repair genes is described. The compilation includes genes encoding DNA repair enzymes, some genes associated with cellular responses to DNA damage, and other genes associated with genetic instability or sensitivity to DNA damaging agents. The updated human DNA repair genes table (http://www.cgal.icnet.uk/DNA_Repair_Genes.htmlhttp://www.cgal.icnet.uk/DNA_Repair_Genes.html) is a research and reference tool that directly links to several databases: Gene Cards, Online Mendelian Inheritance in Man, the NCBI MapViewer for chromosome position, and the NCBI Entrez database for the reference nucleotide sequence. This article discusses the approximately 25 genes added, since the original version of the table was first produced in 2001, and some other revisions.

摘要

本文描述了一份约150个人类DNA修复基因的更新清单。该汇编包括编码DNA修复酶的基因、一些与细胞对DNA损伤反应相关的基因，以及其他与遗传不稳定性或对DNA损伤剂敏感性相关的基因。更新后的人类DNA修复基因表（http://www.cgal.icnet.uk/DNA_Repair_Genes.htmlhttp://www.cgal.icnet.uk/DNA_Repair_Genes.html）是一个研究和参考工具，可直接链接到多个数据库：基因卡片、人类在线孟德尔遗传数据库、用于染色体定位的NCBI地图浏览器，以及用于参考核苷酸序列的NCBI Entrez数据库。本文讨论了自2001年该表的原始版本首次编制以来新增的约25个基因，以及其他一些修订内容。