产前护理中梅毒的治疗：对三剂标准治疗方案的依从性。
Treatment for syphilis in antenatal care: compliance with the three dose standard treatment regimen.
作者信息
Mullick S, Beksinksa M, Msomi S
机构信息
Population Council, Frontiers in Reproductive Health, Hyde Park Lane Manor, EG001 Edinburgh Gate, Hyde Park, Box 411744, Craighall 2024, Johannesburg, South Africa.
出版信息
Sex Transm Infect. 2005 Jun;81(3):220-2. doi: 10.1136/sti.2004.011999.
BACKGROUND
In South Africa, three doses of benzathine penicillin 2.4 MU at weekly intervals are recommended for treating syphilis in pregnancy. Limited information is available on compliance with the recommended regimen, in terms of time to starting treatment, number of doses, and timing of treatment.
METHODS
The study was conducted to establish the degree of compliance with treatment for syphilis. Timing of treatment and the titres of the rapid plasma reagin (RPR) positive women were recorded. A retrospective record review was conducted of 18,128 antenatal records. These were records of women attending antenatal care clinics in a tertiary hospital catchment area in KwaZulu Natal between February 2001 and January 2002.
RESULTS
Treatment patterns showed that 15.9% received no treatment, 13.2% one dose, 5.8% received two doses, and 64.8% received three doses. In total, 188 women (1.03%) were found to be RPR positive. Of these 36% were found to be high titre positives (titre > or = 1:8).
CONCLUSION
Completed treatment was significantly associated with age of gestation at first visit (p = 0.029), with women attending later in pregnancy less likely to receive all three doses of treatment.
背景
在南非，推荐采用苄星青霉素240万单位，每周一次，共三剂的方案治疗妊娠期梅毒。关于在开始治疗的时间、剂量数量和治疗时机方面对推荐方案的依从性，现有信息有限。
方法
开展该研究以确定梅毒治疗的依从程度。记录了治疗时机以及快速血浆反应素（RPR）阳性女性的滴度。对18128份产前记录进行了回顾性记录审查。这些是2001年2月至2002年1月期间在夸祖鲁-纳塔尔省一家三级医院服务区域内产前保健诊所就诊的女性的记录。
结果
治疗模式显示，15.9%未接受治疗，13.2%接受一剂，5.8%接受两剂，64.8%接受三剂。总共发现188名女性（1.03%）RPR呈阳性。其中36%被发现为高滴度阳性（滴度≥1:8）。
结论
完成治疗与首次就诊时的妊娠年龄显著相关（p = 0.029），妊娠后期就诊的女性接受全部三剂治疗的可能性较小。
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