铜绿假单胞菌在M-K保存角膜中的存活情况。
Survival of Pseudomonas aeruginosa in M-K preserved corneas.
作者信息
Panda A, Satpathy G, Sethi H S
机构信息
Dr. Rajendra Prasad Centre of Ophthalmic Sciences, DII/36, AIIMS, New Delhi-110029, India.
出版信息
Br J Ophthalmol. 2005 Jun;89(6):679-83. doi: 10.1136/bjo.2004.050674.
AIM
To present seven eyes of suspected donor to host transmitted Pseudomonas sp corneal graft infection after corneal and scleral graft leading to corneal melting within 24 hours, in a span of 10 months.
METHODS
Case series. Seven eyes, operated for either penetrating or lamellar keratoplasty or scleral patch graft for different indications and which developed massive corneal/corneoscleral infection within 24 hours, were studied prospectively.
RESULTS
Pseudomonas aeruginosa, resistant to almost all antibiotics except polymyxin B in all and vancomycin in two, was identified as the causative organism from all the specimens obtained from the infected graft.
CONCLUSION
Post-keratoplasty infection is a disaster. The source of early infection is invariably iatrogenic. Use of empirical antibiotics in the media is not always sufficient to prevent such infection. Thus, measures must be taken in the form of strict maintenance of asepsis and revision of antibiotics added to the storage medium. Further, early recognition and energetic therapy for such infection could reduce the ophthalmic morbidity.
目的
呈现10个月内7例疑似供体到受体传播的铜绿假单胞菌角膜移植感染病例，这些病例在角膜和巩膜移植后24小时内导致角膜溶解。
方法
病例系列研究。前瞻性研究7例因不同适应证接受穿透性或板层角膜移植术或巩膜补片移植术的患者，这些患者在术后24小时内发生了严重的角膜/角膜巩膜感染。
结果
从感染移植物获取的所有标本中均鉴定出铜绿假单胞菌为病原体，该菌对除多粘菌素B（所有病例）和万古霉素（2例）外的几乎所有抗生素均耐药。
结论
角膜移植术后感染是一场灾难。早期感染的来源总是医源性的。在培养基中使用经验性抗生素并不总是足以预防此类感染。因此，必须采取严格保持无菌和修改添加到储存培养基中的抗生素等措施。此外，对此类感染的早期识别和积极治疗可降低眼科发病率。
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