Chen Susie A, Morris Christopher G, Amdur Robert J, Werning John W, Villaret Douglas B, Mendenhall William M
University of Miami School of Medicine, Florida, USA.
Am J Clin Oncol. 2005 Jun;28(3):259-63. doi: 10.1097/01.coc.0000158440.27229.d6.
To analyze the outcomes of adult patients with head and neck soft tissue sarcomas.
Review of 39 patients treated with radiotherapy (RT) alone (6 patients) or combined with surgery (33 patients) with curative intent between December 1966 and February 2003. Follow-up for living patients ranged from 1 to 21 years (median, 8.7 years).
Five-year outcomes were as follows: local control, 78%; distant metastasis-free survival, 85%; cause-specific survival, 69%, and overall survival, 63%. Three of 6 patients (50%) treated with definitive RT were locally controlled compared with 27 of 33 patients (82%) treated with surgery and RT.
Approximately two thirds of patients with head and neck soft tissue sarcomas are cured with RT alone or combined with surgery. Local recurrence is a significant mode of treatment failure. Outcome is influenced by tumor extent, histologic grade, and resectability.
分析成年头颈部软组织肉瘤患者的治疗结果。
回顾1966年12月至2003年2月间39例接受单纯放疗（RT）（6例）或放疗联合手术（33例）且有治愈意图的患者。对存活患者的随访时间为1至21年（中位数为8.7年）。
五年治疗结果如下：局部控制率为78%；无远处转移生存率为85%；病因特异性生存率为69%，总生存率为63%。接受根治性放疗的6例患者中有3例（50%）实现局部控制，而接受手术联合放疗的33例患者中有27例（82%）实现局部控制。
约三分之二的头颈部软组织肉瘤患者通过单纯放疗或放疗联合手术得以治愈。局部复发是治疗失败的一个重要模式。治疗结果受肿瘤范围、组织学分级和可切除性的影响。
