Ivanyi-Nagy R, Davidovic L, Khandjian E W, Darlix J-L
Unité de Virologie Humaine (412), Ecole Normale Supérieure de Lyon et Institut National de la Santé et de la Recherche Médicale, IFR 128, 46 allée d'Italie, 69 364 Lyon, France.
Cell Mol Life Sci. 2005 Jul;62(13):1409-17. doi: 10.1007/s00018-005-5100-9.
RNA chaperones are ubiquitous proteins that play pivotal roles in cellular RNA metabolism and RNA virus replication. Here we propose that they act by organizing complex and highly dynamic networks of RNA-RNA, RNA-protein and protein-protein interactions. How this is achieved and how their malfunction may lead to disease will be discussed through the examples of human immunodeficiency virus type 1 nucleocapsid protein (NCp7), the fragile X mental retardation protein and the prion protein.
RNA伴侣蛋白是普遍存在的蛋白质，在细胞RNA代谢和RNA病毒复制中发挥关键作用。在此，我们提出它们通过组织RNA-RNA、RNA-蛋白质和蛋白质-蛋白质相互作用的复杂且高度动态的网络来发挥作用。将通过人类免疫缺陷病毒1型核衣壳蛋白（NCp7）、脆性X智力低下蛋白和朊病毒蛋白的例子来讨论这是如何实现的以及它们的功能失调如何导致疾病。
