Park Mi-Kyoung, Deng Suxiang, Advincula Rigoberto C
Department of Chemistry, University of Houston, Houston, Texas 77204, USA.
Langmuir. 2005 Jun 7;21(12):5272-7. doi: 10.1021/la047008x.
We describe the formation and permeability of polyelectrolyte multilayer hollow-shell capsules by photo-cross-linking and controlled-release (fluorescence) studies. The hollow shells were prepared by alternate layer-by-layer (LbL) adsorption of photo-cross-linkable benzophenone modified poly(allylamine hydrochloride) and poly(sodium 4-styrenesulfonate) on polystyrene particles, followed by removing the core with tetrahydrofuran. Zeta potential measurements, fourier transform infrared spectroscopy, and transmission electron microscopy were used to verify the LbL process integrity. A model drug, rhodamine B (RB), was successfully loaded into the polyelectrolyte hollow capsules. The release kinetics of RB was investigated using fluorescence spectroscopy. The permeability of RB through the hollow shells was effectively controlled based on UV irradiation time. It was shown that the release of RB molecules can be controlled by the degree of cross-linking induced in the multilayer.
我们通过光交联和控释（荧光）研究描述了聚电解质多层空心壳胶囊的形成和渗透性。通过将可光交联的二苯甲酮改性聚（烯丙胺盐酸盐）和聚（4-苯乙烯磺酸钠）在聚苯乙烯颗粒上交替逐层（LbL）吸附来制备空心壳，然后用四氢呋喃去除核。使用zeta电位测量、傅里叶变换红外光谱和透射电子显微镜来验证LbL过程的完整性。一种模型药物罗丹明B（RB）成功地负载到聚电解质空心胶囊中。使用荧光光谱研究了RB的释放动力学。基于紫外线照射时间有效地控制了RB通过空心壳的渗透性。结果表明，RB分子的释放可以通过多层中诱导的交联程度来控制。
