Laroute V, Chetboul V, Roche L, Maurey C, Costes G, Pouchelon J-L, De La Farge F, Boussouf M, Lefebvre H P
UMR 181 Physiopathologie et Toxicologie Expérimentales INRA/ENVT, Ecole Nationale Vétérinaire de Toulouse, 23 chemin des Capelles, 31076 Toulouse cedex 03, France.
Res Vet Sci. 2005 Oct;79(2):161-7. doi: 10.1016/j.rvsc.2004.11.011. Epub 2005 Feb 5.
Daily urinary collection and assessment of glomerular filtration rate (GFR) and effective renal plasma flow were performed in ten 2-month-old Beagle puppies and ten 6-9 year-old Beagle dogs to identify age-associated differences in renal function. The most striking differences in puppies compared to mature dogs were a higher daily urinary volume (+65%), GFR (+87%), free water reabsorption (+159%), a lower daily protein excretion (-88%), and fractional excretion of phosphorus (-35%). Renal function in Beagle puppies, but not mature dogs, was also quite different compared to data published in younger adult dogs.
对十只2个月大的比格幼犬和十只6 - 9岁的比格犬进行每日尿液收集，并评估肾小球滤过率（GFR）和有效肾血浆流量，以确定肾功能的年龄相关差异。与成年犬相比，幼犬最显著的差异在于每日尿量增加（+65%）、肾小球滤过率增加（+87%）、自由水重吸收增加（+159%）、每日蛋白质排泄减少（-88%）以及磷的分数排泄减少（-35%）。与年轻成年犬发表的数据相比，比格幼犬的肾功能也有很大不同，但成年犬则不然。
