梭菌毒素在神经元中的内化及作用机制
Internalization and mechanism of action of clostridial toxins in neurons.
作者信息
Grumelli Carlotta, Verderio Claudia, Pozzi Davide, Rossetto Ornella, Montecucco Cesare, Matteoli Michela
机构信息
Department of Medical Pharmacology and CNR Institute of Neuroscience, Center of Excellence for Neurodegenerative Diseases, University of Milano, Via Vanvitelli 32, 20129 Milano, Italy.
出版信息
Neurotoxicology. 2005 Oct;26(5):761-7. doi: 10.1016/j.neuro.2004.12.012. Epub 2005 May 31.
Botulinum toxins are metalloproteases that act inside nerve terminals and block neurotransmitter release via their activity directed specifically on SNARE proteins. This review summarizes data on botulinum toxin modes of binding, sites of action, and biochemical activities. Their use in cell biology and neuroscience is considered, as well as their therapeutic utilization in human diseases characterized by hyperfunction of cholinergic terminals.
肉毒杆菌毒素是金属蛋白酶，作用于神经末梢内部，通过其特异性作用于SNARE蛋白的活性来阻断神经递质释放。本综述总结了关于肉毒杆菌毒素结合模式、作用位点和生化活性的数据。还考虑了它们在细胞生物学和神经科学中的应用，以及它们在以胆碱能末梢功能亢进为特征的人类疾病中的治疗用途。
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