甘氨酸转运体：基因缺失揭示的具有药理学意义的关键作用
Glycine transporters: crucial roles of pharmacological interest revealed by gene deletion.
作者信息
Aragón Carmen, López-Corcuera Beatriz
机构信息
Centro de Biología Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autónoma de Madrid, Consejo Superior de Investigaciones Científicas, 28049 Madrid, Spain.
出版信息
Trends Pharmacol Sci. 2005 Jun;26(6):283-6. doi: 10.1016/j.tips.2005.04.007.
The functions of the high-affinity glycine transporters (GLYTs) in vivo have been revealed recently using gene-deletion studies. Results from studies of homozygous knockout mice have reinforced the idea that GLYTs might be specific clinical targets to modulate inhibitory glycine-mediated neurotransmission. In addition, molecular and behavioural analysis of heterozygous mice has confirmed the therapeutic potential of GLYT1 inhibitors in the treatment of several neurological and psychiatric disorders.
最近，通过基因敲除研究揭示了高亲和力甘氨酸转运体（GLYTs）在体内的功能。对纯合敲除小鼠的研究结果进一步强化了这样一种观点，即GLYTs可能是调节抑制性甘氨酸介导的神经传递的特定临床靶点。此外，对杂合小鼠的分子和行为分析证实了GLYT1抑制剂在治疗几种神经和精神疾病方面的治疗潜力。
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