Yoo Esther M, Morrison Sherie L
Department of Microbiology, Immunology and Molecular Genetics, University of California, 609 Charles E. Young Drive, Los Angeles, CA 90095, USA.
Clin Immunol. 2005 Jul;116(1):3-10. doi: 10.1016/j.clim.2005.03.010.
IgA is a glycoprotein containing multiple N-linked carbohydrates as well as O-linked glycans in the case of IgA1. Because of the critical role it plays in providing protection at mucosal surfaces, IgA is an ideal candidate for use as a therapeutic or prophylactic agent. The presence or absence of carbohydrates, as well as their structure, has been found to influence effector functions and binding to specific IgA receptors. In addition, changes in IgA glycosylation are associated with immune pathology. A thorough understanding of the contributions of the glycans to IgA immune protection will aid in the design of clinically suitable antibodies.
IgA是一种糖蛋白，含有多个N-连接的碳水化合物以及IgA1中的O-连接聚糖。由于它在黏膜表面提供保护方面发挥着关键作用，IgA是用作治疗或预防剂的理想候选物。已发现碳水化合物的存在与否及其结构会影响效应功能和与特定IgA受体的结合。此外，IgA糖基化的变化与免疫病理学相关。深入了解聚糖对IgA免疫保护的作用将有助于设计临床上合适的抗体。
