Zhang Jing, Dong Xin, Fujimoto Yoshito, Okamura Hitoshi
Division of Molecular Brain Science, Department of Brain Sciences, Kobe University Graduate School of Medicine, Kobe, Japan.
Kobe J Med Sci. 2004;50(3-4):101-9.
The circadian rhythm is originally generated by a transcription-translation based oscillatory loop composed of a set of clock genes in most organisms. The clock gene oscillation is generated by the core loop in each neuron of the hypothalamic suprachiasmatic nucleus. Phosphorylation and ubiquitination of clock proteins play the crucial role for the rhythmic transcription of clock genes. The core clock oscillation is conducted at the cellular levels by E-box or by D-box of clock controlled genes.
昼夜节律最初是由大多数生物体中一组时钟基因组成的基于转录-翻译的振荡环产生的。时钟基因振荡由下丘脑视交叉上核每个神经元中的核心环产生。时钟蛋白的磷酸化和泛素化对时钟基因的节律性转录起关键作用。核心时钟振荡在细胞水平上通过时钟控制基因的E盒或D盒进行。
