Lapolla Annunziata, Reitano Rachele, Seraglia Roberta, Sartore Giovanni, Ragazzi Eugenio, Traldi Pietro
Dipartimento di Scienze Mediche e Chirurgiche - Cattedra di Malattie del Metabolismo, Università di Padova, Padova, Italy.
Mol Nutr Food Res. 2005 Jul;49(7):685-90. doi: 10.1002/mnfr.200400093.
Advanced glycation end products (AGE) and dicarbonyl compounds accumulate in serum and tissues of patients with diabetes and chronic renal failure. Pentosidine, free pentosidine, glyoxal and methylglyoxal have been evaluated in plasma of diabetic patients with poor metabolic control at baseline and after the improvement of glycemic levels, and in plasma and peritoneal dialysate of patients with renal failure before and after 12 h of peritoneal dialysis. In diabetic patients, acceptable metabolic control was unable to normalize levels of pentosidine (after 2 and 10 months), glyoxal and methylglyoxal (after 2 months). In patients with end-stage renal disease, mean values of pentosidine, free pentosidine, glyoxal and methylglyoxal decreased in plasma after dialysis. No pentosidine or free pentosidine were present in the peritoneal dialysate at time 0, but were found after 12 h of peritoneal dialysis; glyoxal and methylglyoxal decreased after 12 h of dialysis. So, glyoxal and methylglyoxal, already present in the dialysis fluid, can react with the peritoneal matrix protein, giving a reason for the gradual loss of peritoneal membrane function often observed in patients undergoing long-term peritoneal dialysis.
晚期糖基化终末产物（AGE）和二羰基化合物在糖尿病和慢性肾衰竭患者的血清及组织中蓄积。已对基线时代谢控制不佳以及血糖水平改善后的糖尿病患者血浆，以及腹膜透析12小时前后肾衰竭患者的血浆和腹膜透析液中的戊糖苷、游离戊糖苷、乙二醛和甲基乙二醛进行了评估。在糖尿病患者中，可接受的代谢控制未能使戊糖苷（2个月和10个月后）、乙二醛和甲基乙二醛的水平恢复正常（2个月后）。在终末期肾病患者中，透析后血浆中戊糖苷、游离戊糖苷、乙二醛和甲基乙二醛的平均值下降。在透析开始时腹膜透析液中不存在戊糖苷或游离戊糖苷，但在腹膜透析12小时后被检测到；透析12小时后乙二醛和甲基乙二醛减少。因此，已存在于透析液中的乙二醛和甲基乙二醛可与腹膜基质蛋白发生反应，这解释了长期接受腹膜透析的患者中经常观察到的腹膜功能逐渐丧失的原因。
