猪基因组七个区域连锁不平衡程度的估计。

Estimation of the extent of linkage disequilibrium in seven regions of the porcine genome.

作者信息

Jungerius Bart J, Gu Jingjing, Crooijmans Richard P M A, van der Poel Jan J, Groenen Martien A M, van Oost Bernard A, te Pas Marinus F W

机构信息

Department of Animal Breeding and Genetics, Wageningen University, Wageningen, Netherlands.

出版信息

Anim Biotechnol. 2005;16(1):41-54.

PMID:15926262

Abstract

Linkage disequilibrium (LD) refers to the correlation among neighboring alleles, reflecting non-random patterns of association between alleles at (nearby) loci. A better understanding of LD in the porcine genome is of direct relevance for identification of genes and mutations with a certain effect on the traits of interest. Here, 215 SNPs in seven genomic regions were genotyped in individuals of three breeds. Pairwise linkage disequilibrium was calculated for all marker pairs. To estimate the extent of LD, all pairwise LD values were plotted against the distance between the markers. Based on SNP markers in four genomic regions analyzed in three panels from populations of Large White, Dutch Landrace, and Meishan origin, useful LD is estimated to extend for approximately 40 to 60 kb in the porcine genome.

摘要

连锁不平衡（LD）是指相邻等位基因之间的相关性，反映了（附近）基因座上等位基因之间非随机的关联模式。更好地了解猪基因组中的连锁不平衡对于鉴定对感兴趣的性状有特定影响的基因和突变具有直接相关性。在此，对三个品种个体的七个基因组区域中的215个单核苷酸多态性（SNP）进行了基因分型。计算了所有标记对之间的成对连锁不平衡。为了估计连锁不平衡的程度，将所有成对的连锁不平衡值与标记之间的距离进行绘图。基于在大白猪、荷兰长白猪和梅山猪群体的三个样本中分析的四个基因组区域中的单核苷酸多态性标记，估计在猪基因组中有用的连锁不平衡延伸约40至60千碱基对。