多发性硬化症中的P300：初步报告。

P300 in multiple sclerosis: a preliminary report.

作者信息

Polich J, Romine J S, Sipe J C, Aung M, Dalessio D J

机构信息

Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037.

出版信息

Int J Psychophysiol. 1992 Mar;12(2):155-63. doi: 10.1016/0167-8760(92)90006-w.

DOI:10.1016/0167-8760(92)90006-w

PMID:1592668

Abstract

The P300 component of the event-related brain potential (ERP) elicited with auditory stimuli and pattern-shift visual evoked potentials (VEPs) was obtained from 16 patients with multiple sclerosis (MS) and 16 matched control subjects. P300 latency was significantly longer and component amplitude relatively depressed in the MS patients compared to control subjects. The P100 potential of the VEP also was delayed for both full-field and half-field stimulus conditions in the patients compared to control subjects. The findings suggest that the P300 ERP may reflect the cognitive decline associated with MS.

摘要

通过听觉刺激诱发的事件相关脑电位（ERP）的P300成分以及模式翻转视觉诱发电位（VEP），是从16例多发性硬化症（MS）患者和16例匹配的对照受试者中获得的。与对照受试者相比，MS患者的P300潜伏期明显更长，成分波幅相对降低。与对照受试者相比，患者在全视野和半视野刺激条件下VEP的P100电位也延迟。这些发现表明，P300 ERP可能反映了与MS相关的认知衰退。