Dujardin K, Derambure P, Bourriez J L, Jacquesson J M, Guieu J D
Service d'Explorations Fonctionnelles Neurochirurgicales, CHRU de Lille, France.
Int J Psychophysiol. 1993 May;14(3):255-67. doi: 10.1016/0167-8760(93)90040-v.
The effects of age, stimulus modality and event probability on event-related potentials (ERP) were studied in 12 young and 12 elderly healthy subjects. The ERP were recorded from 15 electrodes referred to linked ears. Results showed that both amplitude and latency of the P300 component are affected by aging. Study of the latency of the earlier ERP components in the two age groups revealed that the P300 delay was not imputable to a delay of the earlier components. P300 amplitude and latency were also affected by event probability and stimulus modality: infrequent stimulus involved higher and later P300, but this effect was more pronounced in the young than in the old group; higher and later P300 were also recorded during the visual task compared to the auditory. Topographical repartition of the brain wave revealed a predominance of the central sites (Fz, Cz, Pz). The findings are discussed in relation to the sensitivity of the ERP assessment procedures in age related modifications of information processing.
在12名年轻和12名老年健康受试者中研究了年龄、刺激方式和事件概率对事件相关电位（ERP）的影响。ERP记录自连接双耳的15个电极。结果显示，P300成分的波幅和潜伏期均受衰老影响。对两个年龄组中较早ERP成分潜伏期的研究表明，P300延迟并非归因于较早成分的延迟。P300波幅和潜伏期也受事件概率和刺激方式影响：罕见刺激涉及更高且更晚出现的P300，但该效应在年轻组中比老年组更明显；与听觉任务相比，视觉任务期间也记录到更高且更晚出现的P300。脑电波的地形分布显示中央部位（Fz、Cz、Pz）占优势。结合ERP评估程序在与年龄相关的信息处理改变中的敏感性对这些发现进行了讨论。
